The National Institutes of Health (NIH) has awarded Dr. Filippo Romiti a grant of $1,950,000 for his project on the New Methods and Strategies for the Scalable Synthesis of Complex Bioactive Molecules. The primary objective of this research is to develop new catalytic stereoselective approaches and synthesis strategies for the creation of polycyclic molecules that hold potential for treating cancer, neurological disorders, and infectious diseases.

This project addresses the challenges associated with the synthesis of complex natural and unnatural compounds, particularly the terpenes and alkaloids known as lead candidates for drug discovery. The goal is to improve access to these promising compounds by creating reliable synthesis methods that overcome the difficulties in accessing their structures. These compounds have remained difficult to synthesize due to their complexity and uncertain mechanisms of action, limiting their development as therapeutic agents.

Dr. Filippo Romiti aims to achieve several objectives through this research, including the development of new chemical changes, innovative synthesis logics, and reliable access to bioactive molecules for use in drug detection. The results of this work will contribute to the advancement of synthetic chemistry, opening up new possibilities for complex molecule synthesis and drug development. These findings will have important suggestions for both scientific research and future medical treatments.