The National Institutes of Health (NIH) has awarded Dr. Hedieh Torabifard $1,935,708 for her research project on Computational Framework to Investigate the Inorganic Ion Transporters. This project intends to address the critical gaps in our understanding of how ions, such as transition metals and anions, are carried across cellular membranes, which is an essential process for maintaining cellular health. Disruptions in these transporters are linked to a range of diseases, including cystic fibrosis, Menkes disease, myotonia, and Wilson’s disease, as well as with antibiotic resistance.

Dr. Hedieh Torabifard will focus on two key families of bacterial transporters: CLCF F-/H+ antiporters and P1B-type ATPases, which are involved in transferring ions like copper (Cu+), zinc (II) ion (Zn2+), and fluoride. The research will discover the selectivity and transport mechanisms of these proteins at the atomic and molecular levels using advanced computational techniques, such as quantum and molecular mechanics, and polarizable force fields.

By investigating the dynamics and local conformational changes of these transporters, identifying key deposits in ion transport, and developing potential inhibitors, this project will contribute to the design of new therapeutic agents. The outcomes will have significant implications for tackling antibiotic resistance and metal-based drug resistance, offering new approaches for the development of effective treatments.

Dr. Hedieh Torabifard’s work represents the National Institutes of Health’s commitment to advancing biomedical research and addressing global health challenges, while also making significant contributions to the field of biology.