Dr. Sven Kroner has been awarded $1,966,165 from the National Institutes of Health for his research on how Vagus Nerve Stimulation Modulates Synaptic Plasticity in the Rat Prefrontal Cortex during the Extinction of Drug-seeking. The experiments in this project will use an animal model of cocaine-seeking to study maladaptive changes in synaptic plasticity that drive drug-seeking and they will determine the mechanisms through which vagus nerve stimulation can reverse these neuronal adaptations to facilitate extinction and reduce relapse.