The Office of Research Integrity and Outreach and Contracts Administration discuss participant payment from the Institutional Review Board’s (IRB) point of view and provide guidance on considerations needed to ensure compliance of applicable regulations and policies that best protect human participants. The University’s new preferred method of compensating research participants is now GalaxyPay, formerly ClinCard. Contracts Administration explains the process of requesting, assigning, and registering the cards once the IRB approval is obtained and answers many of the frequently asked questions related to this payment method.